Methyl Pyruvate CAS 600-22-6 (also known as methyl 2-oxopropanoate or pyruvic acid methyl ester) is a versatile α-keto ester widely used in organic synthesis, pharmaceutical intermediates, flavor & fragrance industry, and biochemical research. It serves as an important building block for the synthesis of heterocycles, amino acids, and various bioactive compounds due to its highly reactive keto and ester functional groups.

 

Technical Specifications

ITEM SPECIFICATION
Appearance Colorless to light yellow transparent liquid
Purity (By GC) ≥98.0%
Water ≤0.5%

 

Packaging & Storage

  • Net weight 200kgs plastic drum, 16MT/FCL with pallets.
  • Store at cool dry place, keep away form light. Protect from moisture and prolonged exposure to air.

 

Primary Applications of Methyl Pyruvate

Pharmaceutical intermediates:
Key precursor for statins, antiviral drugs, and heterocyclic compounds

Organic synthesis:
Used in Knoevenagel, Reformatsky, and aldol-type reactions

Flavor and fragrance industry:
Imparts fruity, caramel-like notes

Biochemical and metabolic research:
Substrate for esterases, transaminases, and pyruvate-related pathway studies

Peptide and amino acid synthesis:
Building block for unnatural amino acids

 

Frequently Asked Questions (FAQs)

Q: What is the difference between Methyl Pyruvate and Ethyl Pyruvate?
A: Methyl Pyruvate (CAS 600-22-6) has a methyl ester group, while Ethyl Pyruvate (CAS 617-35-6) has an ethyl ester. Methyl Pyruvate is slightly more reactive and volatile, with a lower boiling point (134–136 °C vs 144–146 °C).

Q: Is it suitable for pharmaceutical synthesis?
A: Yes. It is widely used as a key intermediate in the synthesis of API molecules, especially in anti-inflammatory, antiviral, and oncology drug candidates.

Q: Is this product suitable for food or flavor applications?
A: Yes, it is FEMA GRAS (No. 2673) and can be used as a flavoring substance within regulatory limits.

Q: Is it stable under basic conditions?
A: No, it undergoes rapid hydrolysis or self-condensation in strong base. Use neutral or mildly acidic conditions when possible.

 

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