Ethyl Pyruvate is a lipophilic, anti-inflammatory, and antioxidant pyruvate derivative widely studied for its potential therapeutic applications in oxidative stress, ischemia-reperfusion injury, sepsis, and neurodegenerative conditions. Unlike sodium pyruvate, Ethyl Pyruvate is stable in solution, readily crosses cell membranes, and exhibits superior pharmacological properties in preclinical models.

 

Technical Specifications

ITEM SPECIFICATION
Appearance Colorless to light yellow transparent liquid
Purity (By GC) ≥98.0%
Water ≤0.5%

 

Packaging & Storage

  • Net weight 200kgs plastic drum, 16MT/FCL with pallets.
  • Store at cool dry place, keep away form light. Protect from moisture and prolonged exposure to air.

 

Primary Applications of Ethyl Pyruvate

Anti-inflammatory & Cytoprotective Studies:
Inhibits HMGB1 release and TLR4/NF-κB pathways in sepsis, ischemia-reperfusion injury, and acute pancreatitis models.

ROS Scavenging & Antioxidant Research:
Directly neutralizes hydrogen peroxide (H₂O₂) and protects cells from oxidative stress.

Metabolic & Energy Research:
Serves as a bioavailable pyruvate source in cell culture and glycolysis studies.

Neurological Research:
Demonstrates neuroprotective effects in stroke, traumatic brain injury, and Alzheimer’s disease models.

Cosmetic & Skincare Formulations:
Used for its anti-glycation, skin-soothing, and redness-reduction properties.

 

Frequently Asked Questions (FAQs)

Q: What is the difference between Ethyl Pyruvate and sodium pyruvate?
A: Ethyl Pyruvate is the ethyl ester of pyruvic acid and is significantly more lipophilic and stable in aqueous solutions than sodium pyruvate. It more easily penetrates cell membranes and resists degradation, making it the preferred form for most in vivo and cell-culture studies.

Q: Can it be used in cosmetic formulations?
A: Yes. Recent publications highlight its antioxidant, anti-glycation, and skin-soothing properties. It is increasingly incorporated into anti-aging serums and post-procedure skincare products.

Q: Is it naturally occurring?
A: It occurs in small amounts in some fermented foods and is rapidly formed in vivo from ethyl alcohol and pyruvate, but commercial material is synthetically produced.

Q: Does it have cosmetic applications?
A: Yes. It is increasingly used in anti-aging and sensitive-skin formulations for its anti-glycation, anti-inflammatory, and redness-reducing properties (INCI name: Ethyl Pyruvate).

 

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