Butyl 4-Aminobenzoate (Butamben)

Butyl 4-Aminobenzoate (Butamben) CAS Number: 94-25-7 Chemical Formula: C₁₁H₁₅NO₂ Molecular Weight: 193.25 g/mol

Butyl 4-aminobenzoate, commonly known as Butamben or Butyl p-aminobenzoate, is a high-purity, white to light yellow crystalline powder or solid. As a long-acting local anesthetic ester of 4-aminobenzoic acid (PABA) and n-butanol, it provides prolonged pain relief by selectively blocking sodium channels in sensory neurons, offering extended duration without significant motor impairment. It is valued in pharmaceutical formulations for its sustained anesthetic effects on skin and mucous membranes.

Key Properties

• Appearance: White to light yellow or off-white crystalline powder/solid
• Density: Approximately 1.1 g/cm³
• Melting Point: 57–61 °C (typically around 60 °C)
• Boiling Point: ~174 °C at 8 mmHg
• Solubility: Insoluble in water (approximately 335 mg/L at 25 °C); soluble in alcohol, benzene, chloroform, ether, and other organic solvents
• Purity Grades Available: ≥98–99% (GC or HPLC) for pharmaceutical and research use
• Other Features: Stable under normal conditions; sensitive to light and moisture in some formulations

Our butyl 4-aminobenzoate is produced to meet stringent specifications with minimal impurities, ensuring reliable performance in anesthetic and related applications.

Primary Applications

Butamben delivers long-lasting local anesthesia and is used across pharmaceutical and medical contexts:

• Chronic Pain Management — Provides extended relief for intractable or chronic pain conditions through prolonged nerve blockade, often in specialized formulations for sustained effect without motor or sensory loss in non-target areas.
• Topical & Surface Anesthesia — Applied for surface numbing of skin and mucous membranes; used in creams, ointments, or combinations (e.g., with benzocaine and tetracaine) for pain and itch relief in dermatological or minor procedural settings.
• Pharmaceutical Formulations — Key ingredient in long-duration local anesthetic preparations, including proprietary products for pain control in specific regions (e.g., oral, dental, or post-surgical applications).
• Research & Neuroscience — Employed in studies of sodium channel inactivation, sensory neuron electrophysiology, and development of novel anesthetics or analgesics targeting peripheral nerves.
• Other Uses — Intermediate in organic synthesis; potential in anti-nociceptive research and formulation development for extended-release anesthetics.

Product Advantages

• High-purity grades (≥98–99%) suitable for pharmaceutical and research-grade applications
• Long-acting profile for sustained anesthesia compared to shorter-duration esters
• Low water solubility contributing to prolonged local effect
• Consistent batch quality with controlled particle size and low impurity levels
• Reliable supply for bulk pharmaceutical, research, or formulation needs

Frequently Asked Questions (FAQs)

What makes Butamben different from other local anesthetics like benzocaine or lidocaine? Butamben is an ester-type anesthetic with a notably longer duration of action due to its low water solubility and selective effects on sensory neuron sodium channels, making it suitable for chronic or prolonged pain relief rather than short procedures.

Is Butyl 4-aminobenzoate soluble in water? No, it has very low solubility in water (~335 mg/L at 25 °C), which contributes to its prolonged local anesthetic effect by limiting rapid systemic absorption.

What purity is recommended for pharmaceutical use? High-purity grades (≥98–99% by GC or HPLC) are standard to ensure safety, efficacy, and minimal impurities in formulations or clinical applications.

How does Butamben provide long-lasting pain relief? It selectively affects inactivation of fast sodium currents in sensory neurons, leading to extended nerve blockade and anti-nociception without broadly impairing motor function.

How should Butyl 4-aminobenzoate be stored? Store in a cool, dry place in tightly sealed, light-protected containers to prevent degradation. Avoid moisture and excessive heat.

Is Butamben considered hazardous? It is generally low hazard for intended use but may cause skin/eye irritation or allergic reactions in sensitive individuals (PABA-related). Use appropriate PPE during handling and follow standard pharmaceutical safety guidelines.

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