Methyl Chloroacetate | CAS 96-34-4 | High-Purity Intermediate for Pharmaceuticals & Agrochemicals
Product Name: Methyl Chloroacetate
CAS Number: 96-34-4
Synonyms: Chloroacetic Acid Methyl Ester, Methyl 2-Chloroacetate, Methyl Monochloroacetate, Methyl Alpha-Chloroacetate
Molecular Formula: C₃H₅ClO₂
Molecular Weight: 108.52 g/mol
Appearance: Colorless to slightly yellow transparent liquid with a characteristic sharp, pungent odor
It is a versatile organochlorine compound widely used as a key chemical intermediate in organic synthesis. This high-reactivity ester serves as an essential building block in the production of pharmaceuticals, agrochemicals, dyes, and other specialty chemicals.
Key Properties of Methyl Chloroacetate
- Boiling Point: 129–130 °C
- Melting Point: -32 to -33 °C
- Density: 1.23–1.24 g/mL at 20–25 °C
- Flash Point: 57 °C (open cup)
- Solubility: Slightly soluble in water (~5.2 g/100 mL at 20 °C); fully miscible with most organic solvents including alcohol, ether, and acetone
- Refractive Index: ~1.42
- Vapor Pressure: ~650 Pa at 20 °C
- Purity (Typical): ≥99.0% (GC)
Primary Applications & Uses
Methyl Chloroacetate is valued for its reactive chloromethyl group, enabling efficient alkylation, acylation, and substitution reactions. Common industrial applications include:
- Pharmaceutical Synthesis — Used as an intermediate in the manufacture of active pharmaceutical ingredients (APIs), including certain antibiotics, anti-inflammatory agents, and other therapeutic compounds.
- Agrochemical Production — Key building block for herbicides, pesticides, and plant growth regulators.
- Dye & Pigment Intermediates — Employed in the synthesis of colorants and related fine chemicals.
- Organic Synthesis — Acts as an alkylating agent in the preparation of various esters, amides, and heterocyclic compounds.
- Other Uses — Solvent in specialized extraction processes and precursor for quaternary ammonium compounds.
Why Choose Our Methyl Chloroacetate?
- Consistent high purity for reliable downstream reactions
- Competitive supply with stable availability
- Strict quality control to meet industrial synthesis standards
- Suitable for research, pilot, and large-scale production
Frequently Asked Questions (FAQs)
What is Methyl Chloroacetate mainly used for?
It is primarily used as a reactive intermediate in pharmaceutical synthesis, agrochemicals, and fine chemical production due to its chloro-substituted ester functionality.
Is Methyl Chloroacetate the same as Ethyl Chloroacetate?
No. it has a methyl ester group (CH₃), while Ethyl Chloroacetate uses an ethyl group (C₂H₅). They serve similar roles but differ in reactivity and volatility.
How should it be stored?
Store in a cool, dry, well-ventilated area away from heat, sparks, open flames, and incompatible materials (strong oxidizers, bases, reducing agents). Keep tightly sealed in original containers.
What safety precautions are needed when handling Methyl Chloroacetate?
This compound is toxic, corrosive, and flammable. It can be fatal if inhaled, swallowed, or absorbed through skin. Use in a fume hood with appropriate PPE (chemical-resistant gloves, goggles, protective clothing, respirator). Avoid contact with skin, eyes, and clothing.
Is it hazardous to the environment?
Yes, it is very toxic to aquatic life. Prevent release into waterways and follow local environmental regulations for disposal.
What is the typical packaging for it?
Available in 200 kg drums, IBC totes, or smaller quantities upon request. Custom packaging options are available.
Can it be used in laboratory research?
Yes, it is commonly used in organic chemistry labs for synthesis experiments, but strict safety protocols must be followed due to its toxicity and corrosivity.
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