N-Methylaniline – CAS No. 100-61-8

N-Methylaniline, chemically denoted as C₆H₅NHCH₃ with CAS Number 100-61-8, is a secondary aromatic amine essential as a chemical intermediate, dye precursor, and solvent in organic synthesis, pharmaceuticals, and polymer production.

ITEM STANDARD RESULT
Appearance Light yellowish oil liquid confirms
Color No SH/T0168-92 2#
Relative Density(15/4℃) 0.987-0.994 0.991
N-Methyl Aniline purity ≧99.00% 99.3%
N,N-Dimethyl Aniline ≦0.7% 0.5%
Aniline ≦0.2% 0.12%   
Water content ≦0.1% 0.03%  
Conclusion: confirm with In-house standard.

Applications-N-Methylaniline

Pharmaceutical and Agrochemical Synthesis

  • Antihistamine Intermediates: Key precursor in the production of drugs like diphenhydramine, via alkylation to form ether linkages.
  • Pesticide Manufacturing: Building block for carbamate insecticides through carbamoylation reactions.

Dye and Pigment Industry

  • Azo Dye Precursors: Diazotized to couple with phenols, yielding vibrant red and orange pigments for textiles and inks.
  • Rubber Antioxidants: Reduced to N-methyl-p-toluidine for stabilizers in tire compounds.

Solvent and Laboratory Uses

  • Reaction Solvent: Medium for organometallic additions and extractions, providing non-coordinating environments.
  • Analytical Reagent: Standard in titration for amine determination and GC calibration.

Why Choose Our N-Methylaniline?

Our N-Methylaniline is vacuum-distilled for water content <0.1% and aniline impurities <0.05%, ensuring >98% yields in Grignard or Buchwald-Hartwig couplings. Pharmaceutical producers achieve cleaner chromatograms and 10-15% reduced purification steps. Available in lab (100g-1kg), technical (25kg drums), and industrial (200kg IBCs) grades, with stabilizer options for air-sensitive needs and full REACH/TSCA compliance.

Frequently Asked Questions (FAQs)

What is N-Methylaniline?

It is a secondary amine with formula C₆H₅NHCH₃ and CAS 100-61-8, used as an intermediate in dyes and pharmaceuticals. It’s a liquid that provides a methylated phenylamine for nucleophilic substitutions.

How is N-Methylaniline synthesized in industry?

Typically via Eschweiler-Clarke reductive amination of aniline with formaldehyde and formic acid, or catalytic hydrogenation, yielding 90-95% selectivity.

Is N-Methylaniline safe for handling?

Handle under fume hood—it’s a skin irritant and potential sensitizer; LD50 >2000 mg/kg oral, but avoid inhalation of vapors.

What is the shelf life of it?

In inert-sealed containers at <20°C, it remains stable for 12-24 months, with minimal oxidation—add BHT inhibitor for extended storage.

Can it be used in cross-coupling reactions?

Yes, with Cu or Pd catalysts for Ullmann-type couplings to aryl halides, forming diarylamines in 70-90% yields under mild conditions.

Does N-Methylaniline dissolve in water-based systems?

Limited solubility requires co-solvents like ethanol; it’s fully miscible with alcohols, ethers, and hydrocarbons for versatile formulations.

What packaging options are available for N-Methylaniline?

We offer 100mL-1L glass bottles for labs, 25kg polyethylene drums, and 200kg steel IBCs, all UN-approved for flammable liquids (UN 2810).

For synthetic routes, purity verification, or custom volumes, our chemistry experts provide dedicated assistance.

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