Salicylamide is a white or slightly pink crystalline powder with mild characteristic odor. It is a non-steroidal anti-inflammatory drug (NSAID) and the amide derivative of salicylic acid. It possesses analgesic, antipyretic, and moderate anti-inflammatory properties. It is widely used both as an active pharmaceutical active ingredient (API) and as a key intermediate in the synthesis of pharmaceutical and agrochemical compounds.

 

Tchenical Specifications

ITEMS SPECIFICATIONS
Appearance White Crystalline Powder
Assay ≥98.0%
Loss on Drying ≤0.5%
Residue on Ignition ≤0.1%
Heavy Metals ≤0.001%
Melting Range 139-142℃

 

Packaging and Storage

  • Net weight 25kg woven bag inner-lined with plastic bag or 25kg fibre drum.
  • Store in tightly closed in a cool, dry place. Protected from light.

 

Main Advantages & Unique Benefits

  • Milder on stomach than aspirin (lower risk of gastric bleeding)
  • Faster onset of analgesic action than aspirin in some studies
  • Excellent solubility in alcohol and propylene glycol
  • Widely accepted in pediatric formulations (pleasant taste when formulated)
  • Lower salicylate toxicity profile compared to aspirin
  • Non-narcotic analgesic suitable for OTC combination products

 

Primary Applications of Salicylamide

  • Active pharmaceutical ingredient in pain relievers, cold & flu medicines, and migraine formulas
  • Key intermediate for synthesis of ethenzamide, labetalol, and certain agrochemicals
  • Component in topical analgesic creams and ointments
  • Veterinary medicines (anti-inflammatory and antipyretic)
  • Combination products with acetaminophen, caffeine, and codeine

 

Frequently Asked Questions (FAQs)

Is salicylamide safer than aspirin for the stomach?
Yes. It causes significantly less gastric irritation and has a lower risk of gastrointestinal bleeding compared to aspirin because it does not undergo acetylation.

Can salicylamide be used in children’s medicines?
Yes. It has been safely used for decades in pediatric formulations worldwide (except where Reye’s syndrome concerns restrict salicylates). Always follow local regulations.

What is the difference between salicylamide and salicylic acid?
Salicylamide is the amide form (–CONH₂) while salicylic acid has a carboxylic acid group (–COOH). Salicylamide has better oral analgesic/antipyretic activity and is less keratolytic action.

Is salicylamide considered a salicylate?
Yes. It is metabolized to salicylate in the body and shares similar therapeutic effects, but with a different pharmacokinetic and side-effect profile.

Can salicylamide be combined with acetaminophen and caffeine?
Yes. It is commonly used in proven OTC combinations for enhanced analgesic effect (e.g., similar to “APC” formulas but gentler).

Does salicylamide have anti-inflammatory effects?
It has moderate anti-inflammatory activity, weaker than aspirin but sufficient for mild inflammatory pain conditions when used at higher doses.

 

Where can I buy high-quality Salicylamide?

You can contact us via email [email protected] for offers and bulk orders.