What is Sodium Methyl Mercaptide (SMM)?
Sodium Methyl Mercaptide (SMM), with the CAS Number 5188-07-8, is a highly effective chemical compound widely used in various industrial applications. Also known as sodium methanethiolate, SMM is a strong nucleophile and a versatile reagent in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and specialty chemicals.
Chemical Properties
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CAS Number: 5188-07-8
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Molecular Formula: CH3SNa
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Appearance: Typically a colorless to pale yellow liquid or solution
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Solubility: Soluble in water and polar organic solvents
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Reactivity: Strong nucleophilic properties, making it ideal for chemical synthesis
Applications
Sodium Methyl Mercaptide is a critical component in several industries due to its unique chemical properties:
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Pharmaceutical Industry
SMM is used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its ability to introduce methylthio groups makes it essential for producing complex drug molecules. -
Agrochemical Manufacturing
In the production of pesticides and herbicides, SMM serves as a building block for creating effective and targeted agrochemical products, enhancing crop protection. -
Specialty Chemicals
SMM is utilized in the synthesis of dyes, fragrances, and other specialty chemicals, offering precision and efficiency in manufacturing processes. -
Polymer and Material Science
It plays a role in modifying polymers and developing advanced materials with specific properties, such as improved durability or chemical resistance.
Safety and Handling
It is highly corrosive, causing severe burns to skin, eyes, and respiratory tract on contact. It is flammable (flash point 27°C) and releases toxic methanol and hydrogen sulfide vapors upon heating or reaction. Inhalation may lead to pulmonary edema, while ingestion risks gastrointestinal perforation (LD50 oral rat ~500 mg/kg). Extremely toxic to aquatic organisms (LC50 <1 mg/L), with persistent effects. Handle exclusively in fume hoods with full PPE: chemical-resistant gloves, face shields, aprons, and SCBA for spills. Store in cool, dry, vented areas under inert gas at <25°C, segregated from acids, oxidizers, and metals. Neutralize spills with dilute acid and absorb; ventilate thoroughly. Evacuate and seek medical aid for exposures. Adhere to SDS protocols for all procedures.
Frequently Asked Questions (FAQs)
What is the main application of sodium methyl mercaptide in pharmaceuticals?
It serves as a nucleophilic reagent for introducing methylthio groups into drug scaffolds, aiding in the synthesis of bioactive compounds with improved pharmacokinetics.
Is sodium methyl mercaptide supplied as a solid or solution?
Typically as a 15-20% aqueous or methanolic solution for safe handling and reactivity; anhydrous solid forms are available but moisture-sensitive.
What are the primary hazards of sodium methyl mercaptide?
It is corrosive to tissues, flammable, and emits toxic vapors; direct contact causes burns, and improper storage risks violent reactions with acids.
How does sodium methyl mercaptide function in organic synthesis?
As a strong nucleophile, it displaces halides or cleaves ethers, enabling efficient C-S bond formation in multistep syntheses.
What concentration levels are standard for industrial sodium methyl mercaptide?
Our offerings feature 15% minimum active content, with customizable up to 25% for specialized reactions, verified by titration.
What storage precautions apply to sodium methyl mercaptide?
Keep under inert atmosphere in sealed containers at <25°C, away from moisture and incompatibles; shelf life reaches 12 months when properly managed.
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