Tert-Butyl Chloroacetate

Tert-Butyl Chloroacetate, also known as chloroacetic acid tert-butyl ester or tert-butyl 2-chloroacetate, is a versatile organic compound widely used as an intermediate in chemical synthesis. With the chemical formula C6H11ClO2 and molecular weight of 150.60 g/mol, this clear, colorless to slightly yellow liquid exhibits excellent reactivity due to its chloroacetyl group protected by a tert-butyl ester. It is commonly employed in pharmaceutical, agrochemical, and specialty chemical industries for its role in facilitating key reactions such as ester condensations and peptide synthesis.

Technical Specifications

Packaging and Storage

• Net weight 200kg drum,16MT/20FCL with pallets.
• Store in a cool, well-ventilated warehouse, away from sources of ignition and heat. The storage temperature should not exceed 30℃. Protect from direct sunlight. Keep the container sealed and store separately from oxidants.

Applications of Tert-butyl Chloroacetate

Tert-butyl Chloroacetate serves as a critical intermediate in various synthetic processes. Here are its primary applications:

Pharmaceutical Synthesis:
Utilized in the production of active pharmaceutical ingredients (APIs), including the synthesis of amino acids, peptides, and chiral compounds like amino alcohols and amine esters. It acts as a building block for novel drug molecules with targeted therapeutic properties.

Agrochemical Production:
Employed in pesticide synthesis to create effective crop protection agents and herbicides, enhancing agricultural yields through precise chemical intermediates.

Specialty Chemicals and Dyes:
Functions as an intermediate for dyes and colorants, contributing to vibrant and high-performance products in the textile and materials industry.

Organic Reactions:
Key reagent in reactions such as the Darzens condensation for glycidic esters, aza-Darzens for aziridine esters, and glycidic ester condensation, enabling the formation of complex structures from ketones and other substrates.

Research and Development:
Ideal for laboratory-scale experiments in organic chemistry, where its reactivity supports the creation of imidazol-1-yl-acetic acid derivatives and other specialized compounds.

Its tert-butyl group provides steric protection, making it suitable for selective reactions in multi-step syntheses.

Frequently Asked Questions (FAQs)

Q: What is Tert-Butyl Chloroacetate used for?
A: It is primarily used as a synthetic intermediate in pharmaceuticals for creating amino acids and peptides, in agrochemicals for pesticide production, and in organic reactions like Darzens condensation.

Q: How should Tert-Butyl Chloroacetate be stored?
A: Store in a cool, dry, well-ventilated area away from moisture, heat sources, and incompatible materials. It is moisture-sensitive and should be kept in a flammable storage area.

Q: Is Tert-Butyl Chloroacetate hazardous?
A: Yes, it is flammable and can cause irritation to eyes, skin, and respiratory system.

Q: Can Tert-Butyl Chloroacetate be used in peptide synthesis?
A: Absolutely, it is commonly employed to prepare peptides and amino acid derivatives due to its protective ester group.

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